ROLE OF TRANSPORTERS IN THE DISTRIBUTION OF PLATINUM-BASED DRUGS

ROLE OF TRANSPORTERS IN THE DISTRIBUTION OF PLATINUM-BASED DRUGS

Platinum derivatives used as chemotherapeutic drugs such as cisplatin and oxaliplatin have a potent antitumor activity.However, severe side effects such as nephro-, oto-, and neurotoxicity are associated with their use.Effects and side effects of platinum-based drugs are in part caused by their transporter-mediated uptake in target and non target c

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Transcriptome sequencing and metabolome analysis of food habits domestication from live prey fish to artificial diets in mandarin fish (Siniperca chuatsi)

Abstract Background As economical traits, food habits domestication can reduce production cost in aquaculture.However, the molecular mechanism underlying food habits domestication has remained elusive.Mandarin fish (Siniperca chuatsi) only feed on live prey fish and refuse artificial diets.In the present study, we domesticated mandarin fish to feed

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Comparison of the Restoration of Breast Feeding after Percutaneous Aspiration vs Incision and Drainage for Management of Breast Abscess

BACKGROUND: Mastitis is not uncommon among lactating woman.This is caused by local inflammation and/or infection of terminal lactiferous ducts.Incision and drainage followed by postoperative antibiotics is the treatment of choice for such abscesses depending on culture and sensitivity.Ultrasound guided needle aspiration is also effective for breast

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